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Article

Downregulation of beta1 integrins by Ebola virus glycoprotein: implication for virus entry.

Virology - 5 Dec 2000

Takada A, Watanabe S, Ito H, Okazaki K, Kida H, Kawaoka Y

Abstract excerpt

Filoviruses, including Ebola virus, are cytotoxic. To investigate the role of the Ebola virus glycoprotein (GP) in this cytopathic effect, we transiently expressed the GP in human kidney 293T cells. Expression of wild-type GP, but not the secretory form of the molecule lacking a membrane anchor, induced rounding and detachment of the cells, as did a chimeric GP containing its ectodomain and influenza virus...

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Source

Identifiers

PMID: 11112476
DOI: 10.1006/viro.2000.0601

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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