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Article

Integrin alpha v beta 5 selectively promotes adenovirus mediated cell membrane permeabilization.

1 Oct 1994

Abstract excerpt

Human adenovirus type 2 (Ad2) enters host cells by receptor-mediated endocytosis, an event mediated by the virus penton base binding to cell surface integrins alpha v beta 3 and alpha v beta 5. While both alpha v integrins promote virus internalization, alpha v beta 5 is involved in the subsequent event of membrane permeabilization. Cells transfected with the beta 5 or beta 3 subunit, expressing either alpha v...

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PMID: 7523420
DOI: 10.1083/jcb.127.1.257

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