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Article

Functional analysis of the -2548G/A leptin gene polymorphism in breast cancer cells.

International journal of cancer - 1 Sept 2009

Terrasi Marianna, Fiorio Elena, Mercanti Anna, Koda Mariusz, Moncada Camilo A, Sulkowski Stanislaw, Merali Salim, Russo Antonio, Surmacz Eva

Abstract excerpt

Leptin is overexpressed in human breast tumors and is produced by breast cancer cells in response to obesity-related stimuli. The leptin promoter polymorphism Lep-2548G/A can be associated with increased leptin secretion by adipocytes and elevated cancer risk. However, molecular mechanisms underlying the link between Lep-2548G/A and breast cancer have never been addressed. Lep-2548G/A is proximal to a binding...

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Identifiers

PMID: 19408304
DOI: 10.1002/ijc.24372

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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