Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Overexpressing leptin genetic polymorphism (-2548 G/A) is associated with susceptibility to prostate cancer and risk of advanced disease.

The Prostate - 15 May 2004

Ribeiro Ricardo, Vasconcelos André, Costa Sandra, Pinto Daniela, Morais Antonio, Oliveira Jorge, Lobo Francisco, Lopes Carlos, Medeiros Rui

Abstract excerpt

BACKGROUND: Leptin has been consistently associated with angiogenesis and tumoral growth. A G/A single nucleotide polymorphism (SNP) at the -2548 site in leptin gene (LEP) is associated with overexpression of leptin (A-allele). METHODS: We evaluated DNA samples from 268 (536 alleles) unrelated individuals, 118 healthy controls (HCs) and 150 prostate cancer (PC) patients, for leptin gene (LEP) locus -2548...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Case-Control Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Progression

Share to DNA, Neoplasm

Share to Gene Expression Regulation, Neoplastic

Share to Leptin

Share to Prostatic Neoplasms

Share to Risk Assessment

Source

Identifiers

PMID: 15042602
DOI: 10.1002/pros.20004

Genes

LEP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Overexpressing leptin genetic polymorphism (-2548 G/A) is associated with susceptibility to prostate cancer and risk of advanced disease.PMID 15042602Read ↗

Genetic polymorphisms in leptin, adiponectin and their receptors affect risk and aggressiveness of prostate cancer: evidence from a meta-analysis and pooled-review.Semantic proximity Read ↗

Genetic G2548A polymorphism of leptin gene and risk of cancer: a meta-analysis of 6860 cases and 7956 controls.Semantic proximity Read ↗

Association of LEP G2548A and LEPR Q223R polymorphisms with cancer susceptibility: evidence from a meta-analysis.Semantic proximity Read ↗

Association of Single Nucleotide Polymorphism -2548 G/A (rs12112075) of leptin gene with endometrial cancer and uterine leiomyomas.Semantic proximity Read ↗

Association Between Leptin (-2548G/A) Genes Polymorphism and Breast Cancer Susceptibility: A Meta-Analysis.Semantic proximity Read ↗

Association of leptin -2548G/A and leptin receptor Q223R polymorphisms with increased risk for oral cancer.Semantic proximity Read ↗

Leptin and prostate: implications for cancer prevention--overview of genetics and molecular interactions.Semantic proximity Read ↗

LEP -2548G>A Polymorphism of the Leptin Gene and Its Influence on the Lipid Profile in Obese Individuals.Semantic proximity Read ↗

The LEP G-2548A gene polymorphism is associated with age at menarche and breast cancer susceptibility.Semantic proximity Read ↗

Functional analysis of the -2548G/A leptin gene polymorphism in breast cancer cells.Semantic proximity Read ↗

LEP (-2548G>A LEP) and LEPR (223Gln>Arg, 109Lys>Arg) polymorphisms as breast cancer risk factors in the Polish female population.Semantic proximity Read ↗

Leptin G-2548A promoter polymorphism is associated with increased plasma leptin and BMI in Brazilian women.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.