Article
Strategies and issues in the detection of pathway enrichment in genome-wide association studies.
Human genetics - 1 Aug 2009
Hong Mun-Gwan, Pawitan Yudi, Magnusson Patrik K E, Prince Jonathan A
Abstract excerpt
A fundamental question in human genetics is the degree to which the polygenic character of complex traits derives from polymorphism in genes with similar or with dissimilar functions. The many genome-wide association studies now being performed offer an opportunity to investigate this, and although early attempts are emerging, new tools and modeling strategies still need to be developed and deployed. Towards this...
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