Article
The Salmonella typhimurium locus mviA regulates virulence in Itys but not Ityr mice: functional mviA results in avirulence; mutant (nonfunctional) mviA results in virulence.
The Journal of experimental medicine - 1 Nov 1991
Benjamin W H, Yother J, Hall P, Briles D E
Abstract excerpt
The virulent Salmonella typhimurium strain WB600 carries the mviA allele of the gene mouse virulence A. As shown here, the virulent phenotype of WB600 is the result of a nonfunctional mviA gene. As compared to the functional allele mviA+, mviA increases virulence in Itys mice, but not in Ityr mic...
Topics
- Alleles
- Animals
- Chromosome Mapping
- Cloning, Molecular
- Genes, Bacterial
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mutation
- Salmonella typhimurium
- Virulence