Treatment of mice with IL-1 before infection increases resistance to a lethal challenge with Salmonella typhimurium. The effect correlates with the resistance allele at the Ity locus.

Abstract excerpt

Administration of a single dose of IL-1 alpha to various strains of mice approximately 16 h before a lethal infection with Salmonella typhimurium resulted in a significant augmentation of survival in most Ityr, but in no Itys strains of mice. Lower numbers of bacteria were observed in the liver a...

Topics

• Alleles
• Animals
• Granulocyte-Macrophage Colony-Stimulating Factor
• Immunity, Innate
• Interleukin-1
• Liver
• Mice
• Mice, Inbred Strains
• Salmonella Infections, Animal
• Salmonella typhimurium
• Spleen