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Article

Relationship between nucleotide binding and ion channel gating in cystic fibrosis transmembrane conductance regulator.

The Journal of physiology - 15 Jun 2009

Aleksandrov Andrei A, Cui Liying, Riordan John R

Abstract excerpt

We have employed rate-equilibrium free energy relationship (REFER) analysis to characterize the dynamic events involved in the allosteric regulation of cystic fibrosis transmembrane conductance regulator (CFTR) function. A wide range of different hydrolysable and poorly hydrolysable nucleoside triphosphates were used to elucidate the role of ATP hydrolysis in CFTR function. The linearity of the REFER plots and...

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Identifiers

PMID: 19403599
DOI: 10.1113/jphysiol.2009.170258
PMCID: PMC2718247

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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