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Article

The non-hydrolytic pathway of cystic fibrosis transmembrane conductance regulator ion channel gating.

The Journal of physiology - 15 Oct 2000

Aleksandrov A A, Chang X, Aleksandrov L, Riordan J R

Abstract excerpt

It has been suggested that the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel may utilize a novel gating mechanism in which open and closed states are not in thermodynamic equilibrium. This suggestion is based on the assumption that energy of ATP hydrolysis drives the gating cycle. We demonstrate that CFTR channel gating occurs in the absence of ATP hydrolysis and hence does not...

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Share to Adenosine Triphosphate
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11034616
DOI: 10.1111/j.1469-7793.2000.00259.x
PMCID: PMC2270135

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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