Tissue-Specific, Hormonal, and Developmental Regulation of<i>SCC-LacZ</i>Expression in Transgenic Mice Leads to Adrenocortical Zone Characterization¹

Abstract excerpt

We report here the study of the human CYP11A1 promoter in driving tissue-specific, developmentally and hormonally regulated reporter gene expression. A 4.4-kb fragment containing all known regulatory elements is more efficient than a short basal promoter fused to an upstream adrenal enhancer in driving reporter LacZ gene expression both in cell culture and in transgenic mice. The LacZ gene controlled by the 4.4-...

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