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Article

Fetal globin expression is regulated by Friend of Prmt1

5 Aug 2010

Abstract excerpt

An estimated 6% to 7% of the earth's population carries a mutation affecting red blood cell function. The β-thalassemias and sickle cell disease are the most common monogenic disorders caused by these mutations. Increased levels of γ-globin ameliorate the severity of these diseases because fetal hemoglobin (HbF; α2γ2) can effectively replace adult hemoglobin (HbA; α2β2) and counteract polymerization of sickle...

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Share to Epigenetics and DNA Methylation
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Identifiers

PMID: 20688955
DOI: 10.1182/blood-2010-03-274399

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