Stable Lyonization of X-linked pgk-1 gene during aging in normal tissues and tumors of mice carrying Searle's translocation.

doi:10.1093/geronj/46.6.b213

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Stable Lyonization of X-linked pgk-1 gene during aging in normal tissues and tumors of mice carrying Searle's translocation.

Journal of gerontology - 1 Nov 1991

Tsukada M, Wada Y, Hamade N, Masuda H, Koizumi A

Abstract excerpt

We investigated whether age-dependent reactivation of a repressed X-linked gene occurs. Subjects were female mice, carrying the X-autosomal translocation, T(X;16)16H (Searle's translocation). The mice were also heterozygous, for the X-linked gene coding for phosphoglycerate kinase (T16H pgk-1b/+ pgk-1a and pgk-1a was selectively repressed in these mice (McMahon and Monk, 1983). An electrophoretic method was...

Topics

Aging
Animals
Brain
Electrophoresis
Erythrocytes
Female
Gene Expression Regulation, Enzymologic
Genetic Linkage
Genotype
Liver
Mice
Mice, Inbred C3H

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred Strains

Myocardium

Neoplasms, Experimental

Phenotype

Phosphoglycerate Kinase

Spleen

Source

Open in PubMed

Identifiers

PMID: 1940071
DOI: 10.1093/geronj/46.6.b213

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1940071-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Stable Lyonization of X-linked pgk-1 gene during aging in normal tissues and tumors of mice carrying Searle's translocation.PMID 1940071Read ↗

Mouse endogenous X-linked genes do not show lineage-specific delayed inactivation during development.Semantic proximity Read ↗

Age-dependent selection against hypoxanthine phosphoribosyl transferase-deficient cells in mouse haematopoiesis.Semantic proximity Read ↗

Loss of the Inactive X Chromosome and Replication of the Active X in BRCA1-Defective and Wild-type Breast Cancer CellsSemantic proximity Read ↗

Expression of selected genes escaping from X inactivation in the 41, XXY* mouse model for Klinefelter’s syndromeSemantic proximity Read ↗

Downregulation of the inflammatory network in senescent fibroblasts and aging tissues of the long‐lived and cancer‐resistant subterranean wild rodent, SpalaxSemantic proximity Read ↗

Reactivation of heritably silenced gene expression in mice.Semantic proximity Read ↗

<i>INK4</i> locus of the tumor-resistant rodent, the naked mole rat, expresses a functional p15/p16 hybrid isoformSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.