Article
Age related reactivation of an X-linked gene.
Nature - 1 Jan 2000
Wareham K A, Lyon M F, Glenister P H, Williams E D
Abstract excerpt
We have investigated age-related reactivation of the X chromosome by devising a model in which reactivation of a single gene in one cell among many can be identified. We have used mice with an X-autosomal translocation giving consistent non-random inactivation of the normal X (as judged by bioche...
Topics
- Aging
- Animals
- Dosage Compensation, Genetic
- Female
- Heterozygote
- Histocytochemistry
- Liver
- Mice
- Mice, Mutant Strains
- Mosaicism
- Mutation
- Ornithine Carbamoyltransferase
- Translocation, Genetic
- X Chromosome