Article
Age related reactivation of an X-linked gene.
Nature - 1 Jan 2000
Wareham K A, Lyon M F, Glenister P H, Williams E D
Abstract excerpt
We have investigated age-related reactivation of the X chromosome by devising a model in which reactivation of a single gene in one cell among many can be identified. We have used mice with an X-autosomal translocation giving consistent non-random inactivation of the normal X (as judged by biochemical and cytogenetic techniques), that also carry a defective form of a histochemically demonstrable X-linked enzyme....
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