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Free energy simulations reveal a double mutant avian H5N1 virus hemagglutinin with altered receptor binding specificity.

Journal of computational chemistry - 1 Aug 2009

Das Payel, Li Jingyuan, Royyuru Ajay K, Zhou Ruhong

Abstract excerpt

Historically, influenza pandemics have been triggered when an avian influenza virus or a human/avian reassorted virus acquires the ability to replicate efficiently and become transmissible in the human population. Most critically, the major surface glycoprotein hemagglutinin (HA) must adapt to the usage of human-like (alpha-2,6-linked) sialylated glycan receptors. Therefore, identification of mutations that can...

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PMID: 19399777
DOI: 10.1002/jcc.21274

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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