Article
Identification of HCV protease inhibitor resistance mutations by selection pressure-based method.
Nucleic acids research - 1 Jun 2009
Qiu Ping, Sanfiorenzo Vincent, Curry Stephanie, Guo Zhuyan, Liu Shaotang, Skelton Angela, Xia Ellen, Cullen Constance, Ralston Robert, Greene Jonathan, Tong Xiao
Abstract excerpt
A major challenge to successful antiviral therapy is the emergence of drug-resistant viruses. Recent studies have developed several automated analyses of HIV sequence polymorphism based on calculations of selection pressure (K(a)/K(s)) to predict drug resistance mutations. Similar resistance analysis programs for HCV inhibitors are not currently available. Taking advantage of the recently available sequence data...
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