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Article

Study of drug resistance-associated genetic mutations, and phylo-genetic analysis of HCV in the Province of Sindh, Pakistan.

Scientific reports - 27 Jul 2023

Faiz Sirmast, Irfan Muhammad, Farooq Saba, Khan Ishtiaq Ahmad, Iqbal Hana'a, Wahab Atia-Tul, Shakeel Muhammad, Gong Peng, Iftner Thomas, Choudhary M Iqbal

Abstract excerpt

Current management of HCV infection is based on Direct-Acting Antiviral Drugs (DAAs). However, resistance-associated mutations, especially in the NS3 and NS5B regions are gradually decreasing the efficacy of DAAs. The aim of the current study was to identify such mutations in the NS3, and NS5B genes in DAAs treatment-naïve Pakistani chronic HCV 3a patients. Peripheral blood samples were collected from 233 chronic...

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Share to Antiviral Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37500705
DOI: 10.1038/s41598-023-39339-4
PMCID: PMC10374889

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