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Article

NBS1 interacts with HP1 to ensure genome integrity.

Cell death & disease - 13 Dec 2019

Bosso Giuseppe, Cipressa Francesca, Moroni Maria Lina, Pennisi Rosa, Albanesi Jacopo, Brandi Valentina, Cugusi Simona, Renda Fioranna, Ciapponi Laura, Polticelli Fabio, Antoccia Antonio, di Masi Alessandra, Cenci Giovanni

Abstract excerpt

Heterochromatin Protein 1 (HP1) and the Mre11-Rad50-Nbs1 (MRN) complex are conserved factors that play crucial role in genome stability and integrity. Despite their involvement in overlapping cellular functions, ranging from chromatin organization, telomere maintenance to DNA replication and repair, a tight functional relationship between HP1 and the MRN complex has never been elucidated. Here we show that the...

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Identifiers

PMID: 31836699
DOI: 10.1038/s41419-019-2185-x
PMCID: PMC6911104

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