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Article

The Group B Streptococcal Serine‐Rich Repeat 1 Glycoprotein Mediates Penetration of the Blood‐Brain Barrier

24 Apr 2009

Abstract excerpt

BACKGROUND: Group B Streptococcus (GBS) is the leading cause of bacterial meningitis in newborn infants. Because GBS is able to invade, survive, and cross the blood-brain barrier, we sought to identify surface-expressed virulence factors that contribute to blood-brain barrier penetration and the pathogenesis of meningitis. METHODS: Targeted deletion and insertional mutants were generated in different GBS clinical...

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Share to Bacterial Infections and Vaccines
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PMID: 19392623
DOI: 10.1086/598217

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