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Article

Random mutagenesis of proximal mouse chromosome 5 uncovers predominantly embryonic lethal mutations.

Genome research - 1 Aug 2005

Wilson Lawriston, Ching Yung-Hao, Farias Michael, Hartford Suzanne A, Howell Gareth, Shao Hongguang, Bucan Maja, Schimenti John C

Abstract excerpt

A region-specific ENU mutagenesis screen was conducted to elucidate the functional content of proximal mouse Chr 5. We used the visibly marked, recessive, lethal inversion Rump White (Rw) as a balancer in a three-generation breeding scheme to identify recessive mutations within the approximately 50 megabases spanned by Rw. A total of 1003 pedigrees were produced, representing the largest inversion screen...

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Identifiers

PMID: 16024820
DOI: 10.1101/gr.3826505
PMCID: PMC1182222

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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