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Article

Conditional linkage and genome-wide association studies identify UGT1A1 as a major gene for anti-atherogenic serum bilirubin levels--the Framingham Heart Study.

Atherosclerosis - 1 Sept 2009

Lin Jing-Ping, Schwaiger Johannes P, Cupples L Adrienne, O'Donnell Christopher J, Zheng Gang, Schoenborn Veit, Hunt Steven C, Joo Jungnam, Kronenberg Florian

Abstract excerpt

OBJECTIVE AND METHODS: Low bilirubin levels are significantly associated with cardiovascular diseases (CVD). In previous genome-wide linkage studies we identified a major locus on chromosome 2q harboring the candidate gene UDP-glucuronosyltransferase (UGT1A1). The activity of this enzyme is significantly influenced by a TA-repeat polymorphism in the promoter of the gene. In a prospective study individuals with...

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Identifiers

PMID: 19389676
DOI: 10.1016/j.atherosclerosis.2009.02.039
PMCID: PMC2752659

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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