Article
Genome-wide association study of electrocardiographic conduction measures in an isolated founder population: Kosrae.
Heart rhythm - 1 May 2009
Smith J Gustav, Lowe Jennifer K, Kovvali Sirisha, Maller Julian B, Salit Jacqueline, Daly Mark J, Stoffel Markus, Altshuler David M, Friedman Jeffrey M, Breslow Jan L, Newton-Cheh Christopher
Abstract excerpt
BACKGROUND: Cardiac conduction, as assessed by electrocardiographic PR interval and QRS duration, is an important electrophysiological trait and a determinant of arrhythmia risk. OBJECTIVE: We sought to identify common genetic determinants of these measures. METHODS: We examined 1604 individuals from the island of Kosrae, Federated States of Micronesia, an isolated founder population. We adjusted for covariates...
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