Article
Mutations of polycomb-associated gene ASXL1 in myelodysplastic syndromes and chronic myelomonocytic leukaemia.
British journal of haematology - 1 Jun 2009
Gelsi-Boyer Véronique, Trouplin Virginie, Adélaïde José, Bonansea Julien, Cervera Nathalie, Carbuccia Nadine, Lagarde Arnaud, Prebet Thomas, Nezri Meyer, Sainty Danielle, Olschwang Sylviane, Xerri Luc, Chaffanet Max, Mozziconacci Marie-Joëlle, Vey Norbert, Birnbaum Daniel
Abstract excerpt
The myelodysplastic syndromes (MDSs) are a heterogeneous group of clonal haematological diseases characterized by ineffective haematopoiesis and predisposition to acute myeloid leukaemia (AML). The pathophysiology of MDSs remains unclear. A definition of the molecular biology of MDSs may lead to a better classification, new prognosis indicators and new treatments. We studied a series of 40 MDS/AML samples by...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.