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Article

S5a promotes protein degradation by blocking synthesis of nondegradable forked ubiquitin chains.

The EMBO journal - 8 Jul 2009

Kim Hyoung Tae, Kim Kwang Pyo, Uchiki Tomoaki, Gygi Steven P, Goldberg Alfred L

Abstract excerpt

Ubiquitin (Ub)-protein conjugates formed by purified ring-finger or U-box E3s with the E2, UbcH5, resist degradation and disassembly by 26S proteasomes. These chains contain multiple types of Ub forks in which two Ub's are linked to adjacent lysines on the proximal Ub. We tested whether cells con...

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Identifiers

PMID: 19387488
DOI: 10.1038/emboj.2009.115
PMCID: PMC2711177

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19387488-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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