Article
Overexpression of UBA5 in Cells Mimics the Phenotype of Cells Lacking UBA5.
International journal of molecular sciences - 4 Jul 2022
Kumari Sujata, Banerjee Sayanika, Kumar Manoj, Hayashi Arata, Solaimuthu Balakrishnan, Cohen-Kfir Einav, Shaul Yoav D, Rouvinski Alexander, Wiener Reuven
Abstract excerpt
Ufmylation is a posttranslational modification in which the modifier UFM1 is attached to target proteins. This conjugation requires the concerted work of three enzymes named UBA5, UFC1, and UFL1. Initially, UBA5 activates UFM1 in a process that ends with UFM1 attached to UBA5's active site Cys. Then, in a trans-thiolation reaction, UFM1 is transferred from UBA5 to UFC1, forming a thioester bond with the latter....
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