Article

Identification of a novel biological role of arenavirus NP exonuclease (exoN) activity in a safe Pichinde virus model

2025-09-09

Abstract excerpt

Arenaviruses such as Lassa virus (LASV) and Junin virus (JUNV) can cause lethal hemorrhagic fever diseases with no FDA-approved vaccines or effective therapeutics. The arenaviral nucleoprotein (NP) contains an exoribonuclease (exoN) domain that suppresses type I interferon (IFN-I) production by degrading pathogen-associated molecular-pattern (PAMP) RNAs. The biological roles of NP exoN during viral infection have...

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Literature Corpus work: 172c243f-5a0b-577a-922d-d2cd50da5872
DOI: 10.1101/2025.09.09.675144

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