Into the matrix: regulation of the iron regulatory hormone hepcidin by matriptase-2.

Abstract excerpt

Matriptase-2 is a recently identified membrane-bound, cell-surface serine protease expressed primarily in liver. Mutations in matriptase-2 in mice and humans cause iron-deficiency anemia that responds poorly to iron therapy. The poor response results from an inability to decrease hepcidin production during iron deficiency. Cell culture studies reveal that matriptase-2 inhibits hepcidin induction by cleaving...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Anemia, Iron-Deficiency
• Share to Antimicrobial Cationic Peptides
• Share to Hepcidins