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Impaired hepcidin expression in alpha-1-antitrypsin deficiency associated with iron overload and progressive liver disease

26 Aug 2015

Abstract excerpt

Liver disease due to alpha-1-antitrypsin deficiency (A1ATD) is associated with hepatic iron overload in a subgroup of patients. The underlying cause for this association is unknown. The aim of the present study was to define the genetics of this correlation and the effect of alpha-1-antitrypsin (A1AT) on the expression of the iron hormone hepcidin. Full exome and candidate gene sequencing were carried out in a...

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PMID: 26310624
DOI: 10.1093/hmg/ddv348

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