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Article

Analysis of somatic mutations in BRAF, CDKN2A/p16 and PI3KCA in patients with medullary thyroid carcinoma.

Molecular medicine reports - 1 Feb 2016

Nascimento Fabrício P, Cardoso Mirian G, Lindsey Susan C, Kunii Ilda S, Valente Flávia O F, Kizys Marina M L, Delcelo Rosana, Camacho Cléber P, Maciel Rui M B, Dias-Da-Silva Magnus R

Abstract excerpt

Medullary thyroid carcinoma (MTC), a neuroendocrine tumor originating from thyroid parafollicular cells, has been demonstrated to be associated with mutations in RET, HRAS, KRAS and NRAS. However, the role of other genes involved in the oncogenesis of neural crest tumors remains to be fully investigated in MTC. The current study aimed to investigate the presence of somatic mutations in BRAF, CDKN2A and PI3KCA in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p16

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Share to Proto-Oncogene Proteins B-raf

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Source

Identifiers

PMID: 26718898
DOI: 10.3892/mmr.2015.4731

Genes

BRAF
HRAS
KRAS
NRAS
RET

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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