Article
Genotypes of alcohol-metabolizing enzymes and the risk for alcoholic chronic pancreatitis in Japanese alcoholics.
Alcoholism, clinical and experimental research - 1 Dec 1996
Matsumoto M, Takahashi H, Maruyama K, Higuchi S, Matsushita S, Muramatsu T, Okuyama K, Yokoyama A, Nakano M, Ishii H
Abstract excerpt
Genetic predisposition to alcoholism and alcoholic liver disease has been reported. However, genetic susceptibility to alcoholic pancreatitis is still a matter of debate. To determine it, we examined genotype patterns of aldehyde dehydrogenase (ALDH2), alcohol dehydrogenase (ADH2 and ADH3), and cytochrome P-4502E1 (CYP2E1) in alcoholic pancreatitis patients. In 296 alcoholic patients, 52 cases showed findings of...
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