Article
APOE and CYP2E1 polymorphisms, alcohol consumption, and Parkinson's disease in a Japanese population.
Journal of neural transmission (Vienna, Austria : 1996) - 1 Sept 2011
Kiyohara Chikako, Miyake Yoshihiro, Koyanagi Midori, Fujimoto Takahiro, Shirasawa Senji, Tanaka Keiko, Fukushima Wakaba, Sasaki Satoshi, Tsuboi Yoshio, Yamada Tatsuo, Oeda Tomoko, Miki Takami, Kawamura Nobutoshi, Sakae Nobutaka, Fukuyama Hidenao, Hirota Yoshio, Nagai Masaki
Abstract excerpt
Apolipoprotein E (APOE) is associated with increased oxidative stress, which is caused by reactive oxygen species (ROS). Enhanced cytochrome P450 2E1 (CYP2E1) activity may also increase formation of neurotoxins such as ROS. As Parkinson's disease (PD) is a neurodegenerative disorder, both the APOE and CYP2E1 genes that are involved in neurodegeneration by oxidative stress may be associated with PD risk. We...
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