Article
Genetic polymorphism of the CYP2E1 gene and susceptibility to Parkinson's disease in Taiwanese.
Journal of neural transmission (Vienna, Austria : 1996) - 1 Nov 2002
Wu R M, Cheng C W, Chen K H, Shan D E, Kuo J W, Ho Y F, Chern H D
Abstract excerpt
Cytochrome p450IIE1 (CYP2E1), an ethanol-inducible cytochrome p450 enzyme, is expressed in the basal ganglia and is probably involved in the activation of neurotoxicants, producing free radical metabolites and resulting in oxidative stress. To examine the association between CYP2E1 polymorphism and the risk of Parkinson's disease (PD), we performed a case-control study on a large population of Taiwanese PD...
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