Article
Absence of association of a single-nucleotide polymorphism in the TERT-CLPTM1L locus with age-related phenotypes in a large multicohort study: the HALCyon programme.
Aging cell - 1 Jun 2011
Alfred Tamuno, Ben-Shlomo Yoav, Cooper Rachel, Hardy Rebecca, Cooper Cyrus, Deary Ian J, Elliott Jane, Gunnell David, Harris Sarah E, Kivimaki Mika, Kumari Meena, Martin Richard M, Power Chris, Sayer Avan Aihie, Starr John M, Kuh Diana, Day Ian N M
Abstract excerpt
Several age-related traits are associated with shorter telomeres, the structures that cap the end of linear chromosomes. A common polymorphism near the telomere maintenance gene TERT has been associated with several cancers, but relationships with other aging traits such as physical capability have not been reported. As part of the Healthy Ageing across the Life Course (HALCyon) collaborative research programme,...
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