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Article

Genetic variation in five genes important in telomere biology and risk for breast cancer.

British journal of cancer - 17 Sept 2007

Savage S A, Chanock S J, Lissowska J, Brinton L A, Richesson D, Peplonska B, Bardin-Mikolajczak A, Zatonski W, Szeszenia-Dabrowska N, Garcia-Closas M

Abstract excerpt

Telomeres, consisting of TTAGGG nucleotide repeats and a protein complex at chromosome ends, are critical for maintaining chromosomal stability. Genomic instability, following telomere crisis, may contribute to breast cancer pathogenesis. Many genes critical in telomere biology have limited nucleotide diversity, thus, single nucleotide polymorphisms (SNPs) in this pathway could contribute to breast cancer risk....

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Identifiers

PMID: 17848914
DOI: 10.1038/sj.bjc.6603934
PMCID: PMC2360388

Genes

TERT
POT1
TEP1

Provenance

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