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Article

Domain duplication, divergence, and loss events in vertebrate Msx paralogs reveal phylogenomically informed disease markers.

BMC evolutionary biology - 20 Jan 2009

Finnerty John R, Mazza Maureen E, Jezewski Peter A

Abstract excerpt

BACKGROUND: Msx originated early in animal evolution and is implicated in human genetic disorders. To reconstruct the functional evolution of Msx and inform the study of human mutations, we analyzed the phylogeny and synteny of 46 metazoan Msx proteins and tracked the duplication, diversification and loss of conserved motifs. RESULTS: Vertebrate Msx sequences sort into distinct Msx1, Msx2 and Msx3 clades. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19154605
DOI: 10.1186/1471-2148-9-18
PMCID: PMC2655272

Genes

MSX1
MSX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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