Article
Replication of KIAA0350, IL2RA, RPL5 and CD58 as multiple sclerosis susceptibility genes in Australians.
Genes and immunity - 1 Oct 2008
Rubio J P, Stankovich J, Field J, Tubridy N, Marriott M, Chapman C, Bahlo M, Perera D, Johnson L J, Tait B D, Varney M D, Speed T P, Taylor B V, Foote S J, Butzkueven H, Kilpatrick T J
Abstract excerpt
A recent genome-wide association study (GWAS) conducted by the International Multiple Sclerosis Genetics Consortium (IMSGC) identified a number of putative MS susceptibility genes. Here we have performed a replication study in 1134 Australian MS cases and 1265 controls for 17 risk-associated single nucleotide polymorphisms (SNPs) reported by the IMSGC. Of 16 SNPs that passed quality control filters, four, each...
Topics
- Adolescent
- Adult
- Aged
- Australia
- CD58 Antigens
- Case-Control Studies
- Child
- Female
- Genetic Predisposition to Disease
- Genome-Wide Association Study
