The SaeR/S Gene Regulatory System Is Essential for Innate Immune Evasion by<i>Staphylococcus aureus</i>

Abstract excerpt

Methicillin-resistant Staphylococcus aureus is problematic both in hospitals and in the community. Currently, we have limited understanding of mechanisms of innate immune evasion used by S. aureus. To that end, we created an isogenic deletion mutant in strain MW2 (USA400) of the saeR/S 2-component gene regulatory system and studied its role in mouse models of pathogenesis and during human neutrophil interaction....

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