Article
Systematic analysis of microRNA targeting impacted by small insertions and deletions in human genome.
PloS one - 1 Jan 2012
Bhattacharya Anindya, Ziebarth Jesse D, Cui Yan
Abstract excerpt
MicroRNAs (miRNAs) are small noncoding RNA that play an important role in posttranscriptional regulation of mRNA. Genetic variations in miRNAs or their target sites have been shown to alter miRNA function and have been associated with risk for several diseases. Previous studies have focused on the most abundant type of genetic variations, single nucleotide polymorphisms (SNPs) that affect miRNA-mRNA interactions....
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