tat regulates binding of the human immunodeficiency virus trans-activating region RNA loop-binding protein TRP-185.

doi:10.1101/gad.5.11.2128

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

tat regulates binding of the human immunodeficiency virus trans-activating region RNA loop-binding protein TRP-185.

Genes & development - 1 Nov 1991

Wu F, Garcia J, Sigman D, Gaynor R

Abstract excerpt

The TAR element extending from -17 to +80 in the human immunodeficiency virus long terminal repeat (HIV LTR) is required for activation of gene expression by the tat trans-activator protein. TAR RNA forms a stable stem-loop structure, and mutagenesis studies indicate that the stem structure, the primary sequence of the loop, and the bulge element are the major determinants for tat activation. RNA gel retardation...

Topics

Amino Acid Sequence
Base Sequence
Cell Fractionation
Chloramphenicol O-Acetyltransferase
Gene Expression Regulation, Viral
Gene Products, tat
HIV Long Terminal Repeat
HIV-1
HeLa Cells
Humans
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Nuclear Proteins

Nucleic Acid Conformation

Plasmids

RNA, Viral

RNA-Binding Proteins

tat Gene Products, Human Immunodeficiency Virus

Source

Open in PubMed

Identifiers

PMID: 1936997
DOI: 10.1101/gad.5.11.2128

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1936997-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

tat regulates binding of the human immunodeficiency virus trans-activating region RNA loop-binding protein TRP-185.PMID 1936997Read ↗

Specific HIV-1 TAR RNA loop sequence and functional groups are required for human cyclin T1-Tat-TAR ternary complex formation.Semantic proximity Read ↗

Characterization of a Human TAR RNA-Binding Protein That Activates the HIV-1 LTRSemantic proximity Read ↗

The sequence and structure of the 3' arm of the first stem-loop of the human immunodeficiency virus type 2 trans-activation responsive region mediate Tat-2 transactivation.Semantic proximity Read ↗

The Structure of the Human Immunodeficiency Virus Type-1 TAR RNA Reveals Principles of RNA Recognition by Tat ProteinSemantic proximity Read ↗

Human immunodeficiency virus type 1 TAR element revertant viruses define RNA structures required for efficient viral gene expression and replication.Semantic proximity Read ↗

The apical loop of the HIV-1 TAR RNA hairpin is stabilized by a cross-loop base pair.Semantic proximity Read ↗

HIV-1 Tat Protein-mediated Transactivation of the HIV-1 Long Terminal Repeat Promoter Is Potentiated by a Novel Nuclear Tat-interacting Protein of110 kDa, Tip110Semantic proximity Read ↗

Cooperative Interaction between HIV-1 Regulatory Proteins Tat and Vpr Modulates Transcription of the Viral GenomeSemantic proximity Read ↗

RNA binding by the tat and rev proteins of HIV-1.Semantic proximity Read ↗

Identification of a Cellular Protein That Specifically Interacts with the Essential Cysteine Region of the HIV-1 Tat TransactivatorSemantic proximity Read ↗

Detailed mutational analysis of TAR RNA: critical spacing between the bulge and loop recognition domains.Semantic proximity Read ↗

Interaction of human immunodeficiency virus type 1 Tat-derived peptides with TAR RNA.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.