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Article

The efficacies of clozapine and haloperidol in refractory schizophrenia are related to DTNBP1 variation.

Pharmacogenetics and genomics - 1 Jun 2009

Zuo Lingjun, Luo Xingguang, Krystal John H, Cramer Joyce, Charney Dennis S, Gelernter Joel

Abstract excerpt

OBJECTIVE: The prototypical atypical antipsychotic agent, clozapine, is more efficacious for refractory schizophrenia than the 'typical' antipsychotics, but the mechanism underlying this enhanced efficacy is still under investigation. Since 2002, at least 22 association studies have shown that the DTNBP1 can be associated with the risk for schizophrenia. We hypothesized that DTNBP1 might also influence the...

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Identifiers

PMID: 19369910
DOI: 10.1097/FPC.0b013e32832b9cfc
PMCID: PMC2857717

Genes

DTNBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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