Article
Association studies between the plasmin genes and late-onset Alzheimer's disease.
Neurobiology of aging - 1 Jul 2007
Shibata Nobuto, Kawarai Toshitaka, Meng Yan, Lee Joseph H, Lee Hye-Seung, Wakutani Yosuke, Shibata Eri, Pathan Nazia, Bi Andrew, Sato Christine, Sorbi Sandro, Bruni Amalia C, Duara Ranjan, Mayeux Richard, Farrer Lindsay A, George-Hyslop Peter St, Rogaeva Ekaterina
Abstract excerpt
The plasmin system is involved in the degradation of Abeta peptides, the accumulation of which in brain is a hallmark of Alzheimer's disease (AD). In a North European case-control AD dataset we studied 14 common variations in the PLG, PAI-1, PLAT and PLI genes encoding components of the plasmin system. Among the four polymorphisms in the PLAT, PAI-1 and PLI genes showing nominally significant evidence for an...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.