Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Japanese encephalitis virus vaccine candidate strain is attenuated by decreasing its interferon antagonistic ability.

Vaccine - 11 May 2009

Liang Jian-Jong, Liao Ching-Len, Liao Jia-Teh, Lee Yi-Ling, Lin Yi-Ling

Abstract excerpt

Japanese encephalitis virus (JEV) is a mosquito-borne flavivirus that causes acute encephalitis with high mortality in humans. To understand the virus-host interactions that influence JEV virulence, we determined the lethality of a neurovirulent (RP-9) and an attenuated (RP-2ms) variant of JEV in several immunodeficient mice strains. The attenuated phenotype of RP-2ms was completely lost in Stat-1-deficient mice,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line
Share to Cell Line, Tumor
Share to Culicidae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Encephalitis Virus, Japanese

Share to Interferons

Share to Mice, Inbred C57BL

Share to Signal Transduction

Share to Vaccines, Attenuated

Source

Identifiers

PMID: 19366580
DOI: 10.1016/j.vaccine.2009.03.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Japanese encephalitis virus vaccine candidate strain is attenuated by decreasing its interferon antagonistic ability.PMID 19366580Read ↗

Generation and characterization of organ-tropism mutants of Japanese encephalitis virus in vivo and in vitro.Semantic proximity Read ↗

A molecularly cloned, live-attenuated japanese encephalitis vaccine SA14-14-2 virus: a conserved single amino acid in the ij Hairpin of the Viral E glycoprotein determines neurovirulence in mice.Semantic proximity Read ↗

Envelope Protein Mutations L107F and E138K Are Important for Neurovirulence Attenuation for Japanese Encephalitis Virus SA14-14-2 StrainSemantic proximity Read ↗

Genetic Determinants of Japanese Encephalitis Virus Vaccine Strain SA14-14-2 That Govern Attenuation of Virulence in Mice.Semantic proximity Read ↗

Comparison of the live-attenuated Japanese encephalitis vaccine SA14 -14-2 strain with its pre-attenuated virulent parent SA14 strain: similarities and differences in vitro and in vivoSemantic proximity Read ↗

Isolation and Transcriptomic Characterization of Genotype 5 Japanese Encephalitis Virus E138K Mutant Strain.Semantic proximity Read ↗

Mapping Attenuation Determinants in Enterovirus-D68Semantic proximity Read ↗

A mouse model for studying viscerotropic disease caused by yellow fever virus infection.Semantic proximity Read ↗

Molecular basis of attenuation of neurovirulence of wild-type Japanese encephalitis virus strain SA14Semantic proximity Read ↗

An attenuating mutation in a neurovirulent Sindbis virus strain interacts with the IPS-1 signaling pathway in vivo.Semantic proximity Read ↗

Vimentin binding is critical for infection by the virulent strain of Japanese encephalitis virusSemantic proximity Read ↗

Biological and genetic properties of SA14-14-2, a live-attenuated Japanese encephalitis vaccine that is currently available for humansSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.