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Article

Generation and characterization of organ-tropism mutants of Japanese encephalitis virus in vivo and in vitro.

Virology - 1 Sept 1996

Chen L K, Lin Y L, Liao C L, Lin C G, Huang Y L, Yeh C T, Lai S C, Jan J T, Chin C

Abstract excerpt

Using gamma-ray irradiation, a pair of virulent (RP-9) and attenuated (RP-2ms) variants of Japanese encephalitis virus (JEV) were generated from a Taiwanese isolate, NT109. The two variants differed in plaque morphology, virus adsorption, and growth properties in BHK-21 cells: (i) RP-2ms produced smaller plaques than RP-9; (ii) RP-2ms adsorbed less efficiently to host cells but yielded a higher virus titer (burst...

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PMID: 8806542
DOI: 10.1006/viro.1996.0457

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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