Article
Generation and characterization of organ-tropism mutants of Japanese encephalitis virus in vivo and in vitro.
Virology - 1 Sept 1996
Chen L K, Lin Y L, Liao C L, Lin C G, Huang Y L, Yeh C T, Lai S C, Jan J T, Chin C
Abstract excerpt
Using gamma-ray irradiation, a pair of virulent (RP-9) and attenuated (RP-2ms) variants of Japanese encephalitis virus (JEV) were generated from a Taiwanese isolate, NT109. The two variants differed in plaque morphology, virus adsorption, and growth properties in BHK-21 cells: (i) RP-2ms produced...
Topics
- Aedes
- Animals
- Cell Line
- Cricetinae
- Culex
- Encephalitis Virus, Japanese
- Encephalitis, Japanese
- Female
- Gamma Rays
- Membrane Glycoproteins
- Mice
- Mice, Inbred BALB C
- Mice, Inbred ICR
- Mutation
- Organ Specificity
- Peritoneum
- Viral Envelope Proteins
- Viral Plaque Assay