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Article

Loss of AND-34/BCAR3 expression in mice results in rupture of the adult lens.

Molecular vision - 1 Jan 2009

Near Richard I, Smith Richard S, Toselli Paul A, Freddo Thomas F, Bloom Alexander B, Vanden Borre Pierre, Seldin David C, Lerner Adam

Abstract excerpt

PURPOSE: AND-34/BCAR3 (Breast Cancer Anti-Estrogen Resistance 3) associates with the focal adhesion adaptor protein, p130CAS/BCAR1. Expression of AND-34 regulates epithelial cell growth pattern, motility, and growth factor dependence. We sought to establish the effects of the loss of AND-34 expression in a mammalian organism. METHODS: AND-34(-/-) mice were generated by homologous recombination. Histopathology, in...

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Share to Epithelium
Share to Gene Targeting

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Guanine Nucleotide Exchange Factors

Share to Lens, Crystalline

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Share to Proto-Oncogene Proteins c-akt

Share to Rupture, Spontaneous

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Source

Open in PubMed Open full text

Identifiers

PMID: 19365570
PMCID: PMC2666772

Genes

BCAR3
BCAR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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