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Article

p130Cas regulates the activity of AND-34, a novel Ral, Rap1, and R-Ras guanine nucleotide exchange factor.

The Journal of biological chemistry - 29 Sept 2000

Gotoh T, Cai D, Tian X, Feig L A, Lerner A

Abstract excerpt

We previously identified a novel murine protein, AND-34, with a carboxyl-terminal domain homologous to Ras family guanine nucleotide exchange factors (GEFs), which bound to the focal adhesion docking protein p130(Cas). Work by others has implicated both the human homologue of AND-34, BCAR3, and human p130(Cas), BCAR1, in the resistance of breast cancer cells to the anti-estrogen tamoxifen. Here we report that...

Read the complete abstract on PubMed

Topics

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Share to GTP Phosphohydrolases
Share to GTPase-Activating Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Guanine Nucleotide Exchange Factors

Share to Guanosine Diphosphate

Share to Proto-Oncogene Proteins pp60(c-src)

Share to ras Proteins

Share to Retinoblastoma-Like Protein p130

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Source

Identifiers

PMID: 10896938
DOI: 10.1074/jbc.M003074200

Genes

BCAR1
BCAR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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p130Cas regulates the activity of AND-34, a novel Ral, Rap1, and R-Ras guanine nucleotide exchange factor.PMID 10896938Read ↗

Breast cancer anti-estrogen resistance 3 (BCAR3) protein augments binding of the c-Src SH3 domain to Crk-associated substrate (p130cas).Semantic proximity Read ↗

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BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells.Semantic proximity Read ↗

AND-34/BCAR3 differs from other NSP homologs in induction of anti-estrogen resistance, cyclin D1 promoter activation and altered breast cancer cell morphology.Semantic proximity Read ↗

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p130CAS Forms a Signaling Complex with the Adapter Protein CRKL in Hematopoietic Cells Transformed by the BCR/ABL OncogeneSemantic proximity Read ↗

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