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Article

CYP2D6 polymorphism and its impact on the clinical response to metoprolol: A systematic review and meta-analysis.

British journal of clinical pharmacology - 1 Jun 2020

Meloche Maxime, Khazaka Michael, Kassem Imad, Barhdadi Amina, Dubé Marie-Pierre, de Denus Simon

Abstract excerpt

AIMS: CYP2D6 genetic polymorphisms are associated with metoprolol pharmacokinetics. Whether the clinical response to metoprolol is also affected remains uncertain. METHODS: We conducted a systematic review on the effects of CYP2D6 polymorphism on the clinical response to metoprolol. Searches were conducted using MEDLINE. Meta-analyses were performed on the impact of CYP2D6-inferred phenotypes on heart rate (HR)...

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Share to Cytochrome P-450 CYP2D6
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32090368
DOI: 10.1111/bcp.14247
PMCID: PMC7256128

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