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Article

Inactivation of Chibby affects function of motile airway cilia.

The Journal of cell biology - 20 Apr 2009

Voronina Vera A, Takemaru Ken-Ichi, Treuting Piper, Love Damon, Grubb Barbara R, Hajjar Adeline M, Adams Allison, Li Feng-Qian, Moon Randall T

Abstract excerpt

Chibby (Cby) is a conserved component of the Wnt-beta-catenin pathway. Cby physically interacts with beta-catenin to repress its activation of transcription. To elucidate the function of Cby in vertebrates, we generated Cby(-/-) mice and found that after 2-3 d of weight loss, the majority of mice die before or around weaning. All Cby(-/-) mice develop rhinitis and sinusitis. When challenged with Pseudomonas...

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Identifiers

PMID: 19364920
DOI: 10.1083/jcb.200809144
PMCID: PMC2700371

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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