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Article

Mutations in a guanylate cyclase GCY-35/GCY-36 modify Bardet-Biedl syndrome-associated phenotypes in Caenorhabditis elegans.

PLoS genetics - 1 Oct 2011

Mok Calvin A, Healey Michael P, Shekhar Tanvi, Leroux Michel R, Héon Elise, Zhen Mei

Abstract excerpt

Ciliopathies are pleiotropic and genetically heterogeneous disorders caused by defective development and function of the primary cilium. Bardet-Biedl syndrome (BBS) proteins localize to the base of cilia and undergo intraflagellar transport, and the loss of their functions leads to a multisystemic ciliopathy. Here we report the identification of mutations in guanylate cyclases (GCYs) as modifiers of...

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Identifiers

PMID: 22022287
DOI: 10.1371/journal.pgen.1002335
PMCID: PMC3192831

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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