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Article

gyrA/B fluoroquinolone resistance allele profiles amongst Mycobacterium tuberculosis isolates from mainland China.

International journal of antimicrobial agents - 1 Jun 2012

Long Quanxin, Li Weimin, Du Qinglin, Fu Yuhong, Liang Qian, Huang Hairong, Xie Jianping

Abstract excerpt

Fluoroquinolones are important second-line drugs for the treatment of tuberculosis. A comprehensive profile of resistance mutation patterns of DNA gyrase, the major target of fluoroquinolones, is crucial for molecular diagnosis of drug resistance and improvement of treatment efficacy. To investigate the mutation types of the genes encoding the A and B subunits of DNA gyrase (gyrA and gyrB, respectively) in...

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Identifiers

PMID: 22526012
DOI: 10.1016/j.ijantimicag.2012.02.015

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