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Article

[Cellular and molecular deregulations driving the metastatic phenotype].

Medecine sciences : M/S - 1 Mar 2009

Zeitoun Guy

Abstract excerpt

Cancerogenesis is initiated by DNA instability that induces modifications in stem cells. Regulation is organ specific and depends on morphogenetic factors. DNA instability is alternatively related to chromosomal aberrations or DNA replication errors. Chromosomal instability is the most frequent characteristics of colon adenocarcinoma, and is observed in distant metastatic foci. It is associated with somatic APC...

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PMID: 19361408
DOI: 10.1051/medsci/2009251s29

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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