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Article

Rectal cancer profiling identifies distinct subtypes in India based on age at onset, genetic, epigenetic and clinicopathological characteristics.

Molecular carcinogenesis - 1 Dec 2015

Laskar Ruhina Shirin, Ghosh Sankar Kumar, Talukdar Fazlur Rahman

Abstract excerpt

Rectal cancer is a heterogeneous disease that develops through multiple pathways characterized by genetic and epigenetic alterations. India has a comparatively higher proportion of rectal cancers and early-onset cases. We analyzed genetic (KRAS, TP53 and BRAF mutations, and MSI), epigenetic alterations (CpG island methylation detection of 10 tumor-related genes/loci), the associated clinicopathological features...

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Source

Identifiers

PMID: 25418895
DOI: 10.1002/mc.22250

Genes

KRAS
BRAF
RASSF1
BRCA1
GSTP1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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